Some people have reported temporary symptoms of peripheral neuropathy (tingling, numbness sensation, decreased sensation to touch or balance difficulties) when taking vitamin B6 in doses above 300 mg daily, especially if the nutrient is taken without other B complex vitamins. This vitamin should not be taken without co-ingestion of equivalent doses of other B-complex vitamins. Consult your physician before taking this vitamin if you are taking levodopa (L-dopa).